Immunological reactivity of animals with tuberculosis under the influence of ionising radiation

Effective control of animal tuberculosis is possible only with a comprehensive examination the biology pathogen, epizootiology, pathogenesis, prevention methods, economic and environmental factors that affect course disease. It known radiation exposure leads to autosensitisation body by breakdown products its tissues development non-specific (false) immunological reactions. Therefore, purpose study was examine (serological) reactivity patients exposed gamma in laboratory animals. Radiological, bacteriological, allergic, serological, pathoanatomical research methods were used study. Guinea pigs consistently irradiated various doses rays, infected Mycobacterium types, and, for 90 days, examined clinical, pathoanatomical, serological complement fixation reaction (CFR) passive hemagglutination (PHGR) according Boyden detect antitubercular complementbinding antibodies tissue autoantibodies. 45 days after infection M. bovis complement-binding recorded serum samples non-irradiated animals diagnostic titres (1:20-1:80), which indicates active infectious process. In intact guinea avium, no anti-tuberculosis detected since are not susceptible causative agent avian tuberculosis. from uninfected pigs, both intact, during entire follow-up period (90 days). The high content autoantibodies blood dose 200 R (0.0516 C/kg) manifestation due damage. presence Mycobacterium-infected did indicators indication antibodies, should be considered when conducting studies veterinary medicine laboratories